According to Anime News Network, director Darren Aronofsky stated that his Lone Wolf and Cub film adapation is no longer in development. According to Aronofsky, the rights to make a film adaptation of Lone Wolf and Cub were never cleared, though he is still interested in directing such an adaptation if the opportunity were to arise.

Darren Aronofsky previously directed Pi, Requiem for a Dream, and The Wrestler.